Modulatory effect of aerobic training on some inflammatory profile indicators in obese females

Introduction: It is widely accepted that low grade systemic inflammation plays a key role in obesity and related diseases and metabolic syndrome. The objective of this work was to evaluate the effect of aerobic training intervention on CRP and IL-10 in adult obese females. Methods: Thirty adult obese women (30&le;BMI&le;36) aged 30 to 40 years were randomly assigned to exercise (3 months aerobic training, 3 time per week at 60-75% of maximum heart rate, n=15) and control (no training, n=15). At baseline and after 3 months, anthropometrical indexes as well fasting serum IL-10 and CRP were assessed in 2 groups. Inter and intra-group changes were analyzed by independent and paired sample T test. P<0.05 was considered statistically signigcant. Results: After the 3 months of aerobic intervention, a significant decrease were observed in BMI, abdominal circumference, body weight, body fat (%) and visceral fat of exercise subjects (P<0.05). No significant difference was found in all variables between 2 groups at baseline (P>0.05). Aerobic intervention resulted in significant increase in serum IL-10 (from 14.79&plusmn;3.04 to 17.79&plusmn;3 pg/ml, P=0.001) and decrease in CRP (from 5670&plusmn;1971 to 3848&plusmn;1092 ng/ml, P=0.002). All variables remained no change in control subjects (P>0.05). Conclusion: With emphasis on IL-10 and CRP, long-term aerobic training can be considered as a anti-inflammatory treatment in sedentary obese females.